Latest Articles on Zika Virus

  • Visualization of the Linear and Spatial Organization of Chromosomes in Mosquitoes Fri, 12 Aug 2022 06:00:00 -0400
    Mosquitoes are vectors of dangerous human diseases such as malaria, dengue, Zika, West Nile fever, and lymphatic filariasis. Visualization of the linear and spatial organization of mosquito chromosomes is important for understanding genome structure and function. Utilization of chromosomal inversions as markers for population genetics studies yields insights into mosquito adaptation and evolution. Cytogenetic approaches assist with the development of chromosome-scale genome assemblies that are...
  • Neurodevelopmental outcomes in a cohort of children with congenital Zika syndrome at one and two years of age Fri, 12 Aug 2022 06:00:00 -0400
    CONCLUSION: Zika virus congenital infection is a risk factor for functional impairments across all developmental domains having a direct and substantial negative impact in early child development.
  • Musculoskeletal pain and quality of life in mothers of children with microcephaly, due to congenital Zika virus syndrome Fri, 12 Aug 2022 06:00:00 -0400
    CONCLUSION: A high prevalence of musculoskeletal pain was observed in mothers of children with microcephaly, with a higher prevalence and intensity in the lumbar spine. The domains related to physical and emotional health presented the worst scores in the quality of life of the evaluated mothers and the presence of musculoskeletal pain reduced the quality of life of the mothers of children with microcephaly in this study.
  • The new invasive mosquito species Aedes koreicus as vector-borne diseases in the European area, a focus on Italian region: What we know from the scientific literature Fri, 12 Aug 2022 06:00:00 -0400
    The increased mobility of goods, people, and animals worldwide has caused the spread of several arthropod vectors, leading to an increased risk of animal and human infections. Aedes koreicus is a common species in South Korea, China, Japan, and Russia. Due to its cold-resistant dormant eggs, the adults last from the late summer until the autumn seasons. For these reasons, it seems to be better adapted to colder temperatures, favoring its colonization of hilly and pre-alpine areas. Its first...
  • The Genomic 3' UTR of Flaviviruses Is a Translation Initiation Enhancer Fri, 12 Aug 2022 06:00:00 -0400
    Viruses rely on the cellular machinery of host cells to synthesize their proteins, and have developed different mechanisms enabling them to compete with cellular mRNAs for access to it. The genus Flavivirus is a large group of positive, single-stranded RNA viruses that includes several important human pathogens, such as West Nile, Dengue and Zika virus. The genome of flaviviruses bears a type 1 cap structure at its 5' end, needed for the main translation initiation mechanism. Several members of...
  • Factors Associated with Behavioral Disorders in Children with Congenital Zika Syndrome and Their Families-A Cross-Sectional Study Fri, 12 Aug 2022 06:00:00 -0400
    The Zika virus was responsible for an outbreak between 2015 and 2016 in Brazil: an alarming public health problem of international relevance. The Congenital Zika Syndrome (CZS) is often associated with manifestations that are responsible for cognitive and motor development delays and behavioral disorders. Thus, we aimed to characterize the clinical-epidemiological and familial context of those children and to identify factors associated with the risk of behavioral disorders using the Survey of...
  • Initial recognition and attachment of the Zika virus to host cells: A molecular dynamics and quantum interaction approach Thu, 11 Aug 2022 06:00:00 -0400
    The zika virus (ZIKV), transmitted to humans from the bites of Aedes Aegypti and Aedes Albopictus mosquitoes produces Zika fever and neurodegenerative disorders that despite affecting millions of people, most recently in Africa and the Americas, has been declared a neglected tropical disease by the World Health Organization. In this work, atomistic molecular dynamics simulations followed by rigorous analysis of the intermolecular interactions reveal crucial aspects of the initial virus···cell...
  • Global trends and hotspots in research on organoids between 2011 and 2020: a bibliometric analysis Wed, 10 Aug 2022 06:00:00 -0400
    CONCLUSIONS: Our study used bibliometric analysis to provide an in-depth understanding of the trends and hotspots of organoid research. The primarily important subject matters are drug screening, disease modeling, personalized medicine, regenerative medicine, and developmental biology. However, this field still faces limitations in the form of lack of reproducibility, low levels of maturity and function, and the absence of appropriate readouts. Therefore, these five significant topics, and...
  • Decline in head circumference growth and associated factors in congenital Zika syndrome Wed, 10 Aug 2022 06:00:00 -0400
    Little is known about the evolution of head circumference (HC) in children with congenital Zika syndrome (CZS). This study aims to evaluate HC growth in children with CZS in the first three years of life and identify associated factors. HC data obtained at birth and in neuropediatric consultations from 74 children with CZS were collected from the Child's Health Handbook, parents' reports, and medical records. Predictors of HC z-score were investigated using different mixed-effects models;...
  • In silico testing of flavonoids as potential inhibitors of protease and helicase domains of dengue and Zika viruses Wed, 10 Aug 2022 06:00:00 -0400
    BACKGROUND: Dengue and Zika are two major vector-borne diseases. Dengue causes up to 25,000 deaths and nearly a 100 million cases worldwide per year, while the incidence of Zika has increased in recent years. Although Zika has been associated to fetal microcephaly and Guillain-Barré syndrome both it and dengue have common clinical symptoms such as severe headache, retroocular pain, muscle and join pain, nausea, vomiting, and rash. Currently, vaccines have been designed and antivirals have been...

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